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26 //
27 //
28 /// \file TLKModel.hh
29 /// \brief Definition of the TLKModel class
30
31 #ifndef TLKMODEL_HH
32 #define TLKMODEL_HH
33
34 //#include <boost/numeric/odeint.hpp>
35 #include <vector>
36 #include <string>
37 class Damage;
38 class TLKModel
39 {
40 public:
41
42 /// \brief constructor
43 TLKModel(double pLambda1 =-1,double pLambda2=-1, double pBeta1=-1, double pBeta2=-1,double pEta=-1);
44 /// \brief destructor
45 ~TLKModel() = default;
46
47 double GetLambda1(){return fLambda1;};
48 void SetLambda1(double pVal){fLambda1 = pVal;};
49 double GetLambda2(){return fLambda2;};
50 void SetLambda2(double pVal){fLambda2 = pVal;};
51 double GetBeta1(){return fBeta1;};
52 void SetBeta1(double pVal){fBeta1 = pVal;};
53 double GetBeta2(){return fBeta2;};
54 void SetBeta2(double pVal){fBeta2 = pVal;};
55 double GetEta(){return fEta;};
56 void SetEta(double pVal){fEta = pVal;};
57
58 double GetSingleDSBYield(){return fSingleDSBYield;};
59 void SetSingleDSBYield(double pVal){fSingleDSBYield = pVal;};
60
61 double GetComplexDSBYield(){return fComplexDSBYield;};
62 void SetComplexDSBYield(double pVal){fComplexDSBYield = pVal;};
63
64 unsigned int GetBpForDSB(){return fBpForDSB;};
65 void SetBpForDSB(unsigned int pVal){fBpForDSB = pVal;};
66
67 double GetStartTime(){return fStartTime;};
68 void SetStartTime(double pVal){fStartTime = pVal;};
69 double GetStopTime(){return fStopTime;};
70 void SetStopTime(double pVal){fStopTime = pVal;};
71 double GetStepTime(){return fStepTime;};
72 void SetStepTime(double pVal){fStepTime = pVal;};
73
74 // Compute damage inputs required by TLK model
75 void ComputeAndSetDamageInput(std::vector<Damage>);
76
77 // Compute SF for a given absorbed dose expressed in Gy
78 double ComputeSF(double pDose);
79
80 // Compute a SF Curve
81 void CalculateRepair(double pDoseMax, double pDeltaDose);
82
83 // Write output, dose expressed in Gy
84 void WriteOutput(std::string pFileName);
85
86 void SetDose(double d) {fDose = d;}
87 private:
88 std::vector<double> TLK_odes_system(double t,std::vector<double> y);
89 // TLK parameters
90 // simple DSB repair probability (h-1)
91 double fLambda1{0};
92 // complex DSB repair probability (h-1)
93 double fLambda2{0};
94 // simple DSB misrepair probability (h-1)
95 double fBeta1{0};
96 // complex DSB misrepair probability (h-1)
97 double fBeta2{0};
98 // binary misrepair probability (h-1)
99 double fEta{0};
100
101 // DSB Yields in Gy-1
102 double fSingleDSBYield{0};
103 double fComplexDSBYield{0};
104
105 // num of bp to consider a DSB for the MakeCluster function
106 // default value is 10
107 unsigned int fBpForDSB{10};
108
109 // Time for integration
110 double fStartTime{0};
111 double fStopTime{0};
112 double fStepTime{0};
113
114 // SF curve
115 std::vector<std::pair<double,double>> fSFCurve;
116 // store dose deposited in nucleus cell
117 double fDose{0};
118 };
119
120 #endif