| Geant4 Cross Reference |
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5 Geant4 - Microbeam example
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7
8 README file
9 --------------------
10
11 CORRESPONDING AUTHO
12
13 S. Incerti (a, *) et al.
14 a. Centre d'Etudes Nucleaires de Bordeaux-Grad
15 (CENBG), IN2P3 / CNRS / Bordeaux 1 University,
16 * e-mail:incerti@cenbg.in2p3.fr
17
18 ---->0. INTRODUCTION.
19
20 The microbeam example simulates the cellular i
21 installed on the AIFIRA electrostatic accelera
22 CENBG, Bordeaux-Gradignan, France. For more in
23 please visit :
24 http://www.cenbg.in2p3.fr/
25
26 ---->1. GEOMETRY SET-UP.
27
28 The elements simulated are:
29
30 1. A switching dipole magnet with fringing fie
31 beam generated by the electrostatic accelerato
32 oriented at 10 degrees from the main beam dire
33
34 2. A circular collimator object, defining the
35 microbeam line entrance;
36
37 3. A quadrupole based magnetic symmetric focus
38 transverse demagnifications of 10. Fringe fiel
39 model.
40
41 4. A dedicated cellular irradiation chamber se
42
43 5. A set of horizontal and vertical electrosta
44 be turned on or off to deflect the beam on tar
45
46 6. A realistic human keratinocyte voxellized c
47 microscopy and taking into account realistic n
48 compositions.
49
50
51 ---->2. EXPERIMENTAL SET-UP.
52
53 The beam is defined at the microbeam line entr
54 5 micrometer in diameter. The beam is then foc
55 quadruplet of quadrupoles in the so-called Dym
56 The beam is sent to the irradiation chamber wh
57 isobutane gas detector for counting purpose be
58 culture foil of the target cell which is immer
59 enclosed within a dish.
60
61 A cell is placed on the polypropylene foil and
62 microbeam. The cell is represented through a 3
63 obtained from confocal microscopy. In the prov
64 are : 359 nm (X) x 359 nm (Y) x 163 nm (Z)
65
66 The primary particle beam parameters are gener
67 measurements performed on the AIFIRA facility.
68 cellular irradiation are 3 MeV alpha particles
69
70 More details on the experimental setup and its
71 be found in the following papers:
72
73 - IN SILICO NANODOSIMETRY: NEW INSIGHTS INTO N
74 RADIATION
75 By Z. Kuncic, H. L. Byrne, A. L. McNamara, S.
76 Publsihed in Comp. Math. Meth. Med. (2012) 147
77
78 - MONTE CARLO MICRODOSIMETRY FOR TARGETED IRRA
79 A MICROBEAM FACILITY
80 By S. Incerti, H. Seznec, M. Simon, Ph. Barber
81 Published in Rad. Prot. Dos. 133, 1 (2009) 2-1
82
83 - MONTE CARLO SIMULATION OF THE CENBG MICROBEA
84 GEANT4 TOOLKIT
85 By S. Incerti, Q. Zhang, F. Andersson, Ph. Mor
86 M.J. Merchant, D.T. Nguyen, C. Habchi, T. Pout
87 Published in Nucl. Instrum. and Meth. B 260 (2
88
89 - A COMPARISON OF CELLULAR IRRADIATION TECHNIQ
90 THE GEANT4 MONTE CARLO SIMULATION TOOLKIT
91 By S. Incerti, N. Gault, C. Habchi, J.L.. Lefa
92 T. Pouthier, H. Seznec. Dec 2006. 3pp.
93 Published in Rad. Prot. Dos. 122, 1-4, (2006)
94
95 - GEANT4 SIMULATION OF THE NEW CENBG MICRO AND
96 By S. Incerti, C. Habchi, Ph. Moretto, J. Oliv
97 Published in Nucl.Instrum.Meth.B249:738-742, 2
98
99 - A COMPARISON OF RAY-TRACING SOFTWARE FOR THE
100 SYSTEMS
101 By S. Incerti et al.,
102 Published in Nucl.Instrum.Meth.B231:76-85, 200
103
104 - DEVELOPMENT OF A FOCUSED CHARGED PARTICLE MI
105 INDIVIDUAL CELLS.
106 By Ph. Barberet, A. Balana, S. Incerti, C. Mic
107 Th. Pouthier. Dec 2004. 6pp.
108 Published in Rev.Sci.Instrum.76:015101, 2005
109
110 - SIMULATION OF CELLULAR IRRADIATION WITH THE
111 GEANT4.
112 By S. Incerti, Ph. Barberet, R. Villeneuve, P.
113 C. Michelet-Habchi, Ph. Moretto, D.T. Nguyen,
114 Published in IEEE Trans.Nucl.Sci.51:1395-1401,
115
116 - SIMULATION OF ION PROPAGATION IN THE MICROBE
117 GEANT4.
118 By S. Incerti, Ph. Barberet, B. Courtois, C. M
119 Ph. Moretto. Sep 2003.
120 Published in Nucl.Instrum.Meth.B210:92-97, 200
121
122
123 ---->3 VISUALIZATION
124
125 The user can visualize the targeted cell thank
126
127 ---->4. HOW TO RUN THE EXAMPLE
128
129 The code should be compiled with cmake.
130
131 Run the example from your build directory with
132 ./microbeam microbeam.mac
133
134 or in interactive mode:
135 ./microbeam
136
137 The example works in MT mode.
138
139 ---->5. PHYSICS
140
141 Livermore physics list is used by default.
142
143 ---->6. SIMULATION OUTPUT AND RESULT ANALYZIS
144
145 The output results consist in a microbeam.root
146 containing several ntuples:
147
148 * total deposited dose in the cell nucleus and
149 cytoplasm by each incident alpha particle;
150
151 * average on the whole run of the dose deposit
152 Voxel per incident alpha particle;
153
154 * final stopping (x,y,z) position of the incid
155 alpha particle within the irradiated medium (c
156
157 * stopping power dE/dx of the incident
158 alpha particle just before penetrating into th
159
160 * beam transverse position distribution (X and
161 just before penetrating into the targeted cell
162
163 These results can be easily analyzed using for
164 file plot.C; to do so :
165 * be sure to have ROOT installed on your machi
166 * be sure to be in the directory where the out
167 * do: root plot.C
168 * or under your ROOT session, type in : .X plo
169
170 ----------------------------------------------
171
172 Should you have any enquiry, please do not hes
173 incerti@cenbg.in2p3.fr